'He gave me this explanation: "The fourth beast is a fourth kingdom that will appear on the earth. It will be different from all the other kingdoms and will devour the whole earth, trampling it down and crushing it. The ten horns are ten kings who will come from this kingdom. After them another king will arise, different from the earlier ones; he will subdue three kings. He will speak against the Most High and oppress his saints and try to change the set times and the laws. The saints will be handed over to him for a time, times and half a time."'
The Roman Empire was not defeated but was split in two with the western half based in Rome and the eastern half in Constantinople.The city would become the capitol of the Ottoman Empire which would dominate what we call the Middle East. At the end of World War 1, the empire was broken up into ten pieces: Turkey, Syria, Lebanon, Palestine, Transjordan, Kingdom of Hejer, Sultanate of Nejd, Yemen, and the Arab States of the Persian Gulf (United Arab Emirates). The Kingdom of Hejer & the Sultanate of Nejd became a part of Saudi Arabia. We see that the saints will be handed over to the antichrist for a period of time that is generally called the first half of the Great Tribulation.