Daniel 5:22 - 24

"'But you his son, O Belshazzar, have not humbled yourself, though you knew all this. Instead, you have set yourself up against the Lord of heaven. You had the goblets from his temple brought to you, and you and your nobles, your wives and your concubines drank wine from them. You praised the gods of silver and gold, of bronze, iron, wood and stone, which cannot see or hear or understand. But you did not honor the God who holds in his hand your life and all your ways. Therefore he sent the hand that wrote the inscription.'" NIV translation

Belshazzar had known about what had happened with his grandfather but did not take it to heart. Instead, he went about partying it up and even went so far as to defile the things of God. He worshiped the material things (false gods) and ignored the fact that God was in charge of his life. Daniel tells him that this is the reason that God sent the hand to proclaim his fate. This same type of thing is happening more and more today as many people chase material things and forget the more important matters of life itself.

Daniel 5:25 - 28

"'This is the inscription that was written: MENE, MENE, TEKEL, PARSIN This is what these words mean: Mene: God has numbered the days of your reign and brought it to an end. Tekel: You have been weighed on the scales and found wanting. Peres: Your kingdom is divided and given to the Medes and Persians.'" NIV translation

God simply was telling Belshazzar that his number was up and his kingdom was going to be split in two because of the fact that he did not acknowledge that God was in charge. This is the same thing that God had showed Belshazzar's grandfather as we saw in chapter 2 with the statue.