"Pray that I may proclaim it clearly, as I should." NIV translation
Paul asks for specific prayer in that he simply wants help from God to clearly proclaim the good news that Jesus died for our sins and was raised from the dead so that we may have eternal life. That is a very short presentation of the gospel but the message gets through because of the power of God. Today, many want to add a bunch of their words to the gospel in hopes of luring someone to salvation but that is not what Paul was called to do and it is not what we are either.
"Be wise in the way you act toward outsiders; make the most of every opportunity." NIV translation
Each person that we meet who does not know Jesus is an opportunity to share the good news. We are to be wise not only in the words that we say but also in our actions as they speak just as loudly if not louder than the words. That wisdom can only come from God through the working of the Holy Spirit within us.
"Let your conversation be always full of grace, seasoned with salt, so that you may know how to answer everyone." NIV translation
One of the biggest ways that we interact with others is through talking and here we are reminded to guard our tongues in order to speak the truth in love. This is a very big challenge for most of us as the apostle James described in his letter but we can do it through the power of the Holy Spirit.
"Tychicus will tell you all the news about me. He is a dear brother, a faithful minister and fellow servant in the Lord. I am sending him to you for the express purpose that you may know about our circumstances and that he may encourage your hearts." NIV translation
This final part of the letter to the Colossians contains a list of the people that worked with Paul in spreading the gospel. Tychicus was the pastor of the church in Ephesus and Paul was sending him to minister to the Colossian believers even though they were not a part of "his congregation". This can remind us that we are all a part of the same "team" which is the body of Christ.